COMO COLETAR E PROCESSAR AMOSTRAS

 

Clique AQUI e veja os detalhes

 

 

Biological Rythm Interview of Assessment in Neropsychiatry 

Clique AQUI

Portador de Transtorno Bipolar e familiar - Assista o vídeo com a matéria apresentada no CANAL SAÚDE - clique aqui

Entrevista com o Professor Kapczinski, clique aqui
 

FALE CONOSCO

lisisoria@gmail.com

Fone: 51 - 3359 8845

Cel: 51 - 9972 6283

Fax: 51 - 3359 8846

    

 

 

Declaração de Helsinki I

Laura Stertz e Gabriel Fries recebem prêmio na Reitoria (clique e veja)

Manual Stabilitas para leigos

Clique na figura

 

 

Laboratório de Psiquiatria Molecular: produção científica de nível internacional

 

Com mais de cem trabalhos científicos indexados - as pesquisas que aparecem em publicações de prestígio internacional - o Prof. da Famed, Flávio Kapczinski, e sua equipe no HCPA, são destaque no país, alcançando repercussão no exterior em função de pesquisas para o tratamento do transtorno bipolar.

 

O distúrbio bipolar pode desencadear uma série de doenças não-psiquiátricas por meio da deterioração do DNA. Ao demonstrar o mecanismo celular por meio do qual o problema ocorre, o grupo liderado por Kapczinski propõe uma mudança no tratamento de pacientes bipolares.

 

A descoberta foi divulgada em um estudo na revista "Psychiatry Research", no início de outubro de 2007. O trabalho já está repercutindo no meio médico, após ter sido divulgado também pelo site da Associação Psiquiátrica Americana. No estudo, Kapczinski mostra que o dano ao DNA é produzido por causa do mau funcionamento das mitocôndrias, as estruturas responsáveis por processar a energia da célula.

 

O trabalho dos pesquisadores gaúchos rendeu parceria com a Universidade da Colúmbia Britânica, no Canadá, e com um grupo de pesquisa que acompanha pacientes bipolares em Sydney e em Geelong, na Austrália. Em breve, será feito um ensaio clínico com pacientes em Porto Alegre.

 

Formado em 1986, na Faculdade de Medicina da UFRGS, Kapczinski desenvolve pesquisas nessa área desde 1997. A partir de 2002, quando abriu o Laboratório de Psiquiatria Molecular no Centro de Pesquisas do Hospital de Clínicas, houve evolução acentuada nas pesquisas.

 

Em 2007, o grupo, que inclui bolsistas, alunos de mestrado, doutorado e pós-doutorado, publicou 30 trabalhos em revistas científicas internacionais. Nos últimos dois anos, foram 60 trabalhos indexados. "É um marco, porque nivela em produção com grandes centros internacionais, mas isso só é possível pela qualificação da Famed e do Hospital de Clínicas, onde encontramos um ambiente de excelência para trabalhar", comenta o pesquisador, acrescentando que mais importante que os artigos indexados é a "formação de recursos humanos".

 

TRANSTORNO BIPOLAR

 

O transtorno bipolar (TBP), antigamente chamado de transtorno maníaco-depressivo, tem como característica fundamental episódios de mania alternados com depressão. Ocorre em 1% da população mundial. É um transtorno psiquiátrico potencialmente incapacitante, que pode ser tratado com sucesso. O tratamento adequado reduz a incapacitação e mortalidade de portadores. A mortalidade em pacientes bipolares está aumentada devido a maiores taxas de suicídio, doenças cardiovasculares e neoplasias. Não se conhece o mecanismo exato pelo qual o tratamento pode reduzir a mortalidade do transtorno bipolar, mas aparentemente a redução dos episódios de mania e depressão tem um papel importante.

 

O TBP apresenta uma base genética bem estabelecida. 50% dos portadores do TBP apresentam um familiar afetado. Filhos de portadores do TBP têm risco aumentado de apresentarem a doença, comparados com a população em geral.

 

Existe uma discussão entre os especialistas se formas mais leves do transtorno bipolar, chamadas de "espectro bipolar" devem ou não ser tratadas. Não há um consenso sobre este assunto, mas existem potenciais benefícios (portadores de formas leves podem beneficiar-se de tratamentos) e riscos (o tratamento pode não ser eficaz nestes pacientes) que ficam, então, indevidamente expostos a medicamentos. Pesquisas sobre o "espectro bipolar" apontam para uma prevalência de até 8% destes transtornos na comunidade.

 

O "Programa de Transtorno Bipolar" é um grupo de pesquisa cadastrado no CNPq dedicado ao estudo desta doença, suas potenciais causas e tratamentos. O líder do grupo de pesquisa é o Professor Flávio Kapczinski, do Departamento de Psiquiatria e Medicina Legal da UFRGS. O programa de pesquisa funciona em parceria com o PROTAHBI, programa de tratamento do transtorno bipolar do Hospital de Clínicas de Porto Alegre (HCPA). O PROTAHBI é coordenado pelos Professores e Psiquiatras Aida Santin e Flávio Kapczinski, do mesmo Departamento. As pesquisas realizam-se no Laboratório de Psiquiatria Molecular do HCPA, gerenciado pela pós-doutora do CNPq e Farmacêutica, Keila Ceresér. A equipe de pesquisa inclui profissionais e alunos de diferentes áreas do conhecimento. Os resultados das pesquisas do grupo são publicados em revistas especializadas de circulação internacional.

 

O grupo recentemente recebeu um "Grant" para "Clinical Trial", da Stanley Medical Research (Flávio Kapczinski, Benício Noronha Frey e Márcia Kauer-Sant’anna) e duas premiações internacionais:

 

Independent Investigator da NARSAD (The Mental Health Research Association), para Flávio Kapczinski

 

Young Investigator da NARSAD (The Mental Health Research Association), para Márcia Kauer Sant'anna

 

 

 

Veja alguns artigos do grupo publicados em periódicos a partir do ano de 2005:

 

·         Rosa AR, Reinares M, Michalak EE, Bonnin CM, Sole B, Franco C, Comes M, Torrent C, Kapczinski F, Vieta E. Functional Impairment and Disability across Mood States in Bipolar Disorder. Value Health. 2010 Jul 23. [Epub ahead of print].

·         Magalhães PV, Kapczinski NS, Kapczinski F. Correlates and impact of obsessive compulsive comorbidity in bipolar disorder. Compr Psychiatry. 2010 Jul-Aug;51(4):353-6.

·         Kapczinski F, Dal-Pizzol F, Teixeira AL, Magalhaes PV, Kauer-Sant'anna M, Klamt F, Moreira JC, Augusto de Bittencourt Pasquali M, Fries GR, Quevedo J, Gama CS, Post R. Peripheral biomarkers and illness activity in bipolar disorder. J Psychiatr Res. 2010 Jun 10. [Epub ahead of print].

·         Barichello T, Belarmino E Jr, Comim CM, Cipriano AL, Generoso JS, Savi GD, Stertz L, Kapczinski F, Quevedo J. Correlation between behavioral deficits and decreased brain-derived neurotrophic [correction of neurotrofic] factor in neonatal meningitis. J Neuroimmunol. 2010 Jun;223(1-2):73-6.

·         Kapczinski F, Dal-Pizzol F, Teixeira AL, Magalhaes PV, Kauer-Sant'anna M, Klamt F, de Bittencourt Pasquali MA, Quevedo J, Gama CS, Post R. A systemic toxicity index developed to assess peripheral changes in mood episodes. Mol Psychiatry. 2010 Aug;15(8):784-6.

·         Hallak JE, Crippa JA, Quevedo J, Roesler R, Schröder N, Nardi AE, Kapczinski F. National Science and Technology Institute for Translational Medicine (INCT-TM): advancing the field of translational medicine and mental health. Rev Bras Psiquiatr.2010 Mar;32(1):83-90.

·         Aguiar AS Jr, Speck AE, Prediger RD, Kapczinski F, Pinho RA. Downhill training upregulates mice hippocampal and striatal brain-derived neurotrophic factor levels. J Neural Transm. 2008 Sep;115(9):1251-5.

·         Aguiar AS Jr, Tuon T, Pinho CA, Silva LA, Andreazza AC, Kapczinski F, Quevedo J, Streck EL, Pinho RA. Intense exercise induces mitochondrial dysfunction in mice brain. Neurochem Res. 2008 Jan;33(1):51-8.

·         Andersen ML, Margis R, Frey BN, Giglio LM, Kapczinski F, Tufik S. Electrophysiological correlates of sleep disturbance induced by acute and chronic administration of d-amphetamine. Brain Research. 2008.

·         Andreazza AC, Kauer-Sant'anna M, Frey B, Stertz L, Zanotto C, Ribeiro L, Giasson K, Valvassori SS, Reus GZ, Salvador M, Quevedo J, Gonçalves CA, Kapczinski F. Effects of mood stabilizers on DNA damage in an animal model of mania. Journal of Psychiatry & Neuroscience. 2008. 33: 516-524.   Para ver o artigo na íntegra, clique aqui

·         Andreazza AC, Kauer-Sant'anna M, Frey BN, Bond DJ, Kapczinski F, Young LT, Yatham LN. Oxidative stress markers in bipolar disorder: A meta-analysis. J Affect Disord. 2008 Jun 6. [Epub ahead of print]

·         Berk M, Malhi GS, Hallam K, Gama CS, Dodd S, Andreazza AC, Frey BN, Kapczinski F. Early intervention in bipolar disorders: Clinical, biochemical and neuroimaging imperatives. J Affect Disord. 2008 Sep 25. [Epub ahead of print] Para ver o artigo na íntegra, clique aqui

·         Brietzke E, Kapczinski F. TNF-alpha as a molecular target in bipolar disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2008 Aug 1;32(6):1355-61. Para ver o artigo na íntegra, clique aqui

·         Brissos S, Dias VV, Kapczinski F.Cognitive performance and quality of life in bipolar disorder. Can J Psychiatry. 2008. 53(8):517-24.

·         Busnello JV, Oses JP, da Silva RS, Feier G, Barichello T, Quevedo J, Böhmer AE, Kapczinski F, Souza DO, Sarkis JJ, Portela LV. Peripheral nucleotide hydrolysis in rats submitted to a model of electroconvulsive therapy. Prog Neuropsychopharmacol Biol Psychiatry. 2008 Aug 17. [Epub ahead of print]

·         Cardoso BM, Kauer Sant'Anna M, Dias VV, Andreazza AC, Ceresér KM, Kapczinski F. The impact of co-morbid alcohol use disorder in bipolar patients. Alcohol. 2008. 42(6):451-7. Para ver o artigo na íntegra, clique aqui

·         Cunha AB, Andreazza AC, Gomes FA, Frey BN, da Silveira LE, Gonçalves CA, Kapczinski F. Investigation of serum high-sensitive C-reactive protein levels across all mood states in bipolar disorder.Eur Arch Psychiatry Clin Neurosci. 2008. 258(5):300-4. Para ver o artigo na íntegra, clique aqui

·         Dias VV, Brissos S, Cardoso C, Andreazza AC, Kapczinski F. Serum homocysteine levels and cognitive functioning in euthymic bipolar patients. J Affect Disord. 2008 Jun 24. [Epub ahead of print]

·         Dias VV, Brissos S, Frey BN, Kapczinski F. Insight, quality of life and cognitive functioning in euthymic patients with bipolar disorder. J Affect Disord. 2008. 110(1-2):75-83. Para ver o artigo na íntegra, clique aqui

·         Gama CS, Salvador M, Andreazza AC, Lobato MI, Berk M, Kapczinski F, Belmonte-de-Abreu PS. Elevated serum thiobarbituric acid reactive substances in clinically symptomatic schizophrenic males. Neurosci Lett. 2008. 433(3):270-3. Para ver o artigo na íntegra, clique aqui

·         Garcia LS, Comim CM, Valvassori SS, Reus GZ, Andreazza AC, Stertz L, Fries GR, Gavioli E, Kapczinski F, Quevedo J. Chronic administration of ketamine elicits antidepressant-like effects in rats without affecting hippocampal brain-derived neurotrophic factor protein levels.. Basical & Clinical pharmacology & Toxicology. 2008. 103: 502-506.

·         Garcia LS, Comim, CM, Valvassor, SS, Réus GZ, Barbosa LM, Andreazza AC, Stertz L, Fries GR, Gavioli EC, Kapczinski F, Quevedo J. Acute administration of ketamine induces antidepressant-like effects in the forced swimming test and increases BDNF levels in the rat hippocampus. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2008. 32:140- 144.

·         Garcia LS, Comim CM, Valvassori SS, Réus GZ, Barbosa LM, Andreazza AC, Stertz L, Fries GR, Gavioli EC, Kapczinski F, Quevedo J. Acute administration of ketamine induces antidepressant-like effects in the forced swimming test and increases BDNF levels in the rat hippocampus. Prog Neuropsychopharmacol Biol Psychiatry. 2008. 32(1):140-4.

·         Giglio LMF, Andreazza AC, Andersen M, Ceresér KMM, Walz JC, Stertz L, Kapczinski F. Sleep in bipolar disorders. Sleep and Breathing. 2008. Para ver o artigo na íntegra, clique aqui

·         Gonçalves DM, Kapczinski F. [Mental disorders in a community assisted by the Family Health Program]Cad Saude Pública. 2008. 24(7):1641-50.

·         Gonçalves DM, Kapczinski F. [Prevalence of mental disorders at a referral center for the Family Health Program in Santa Cruz do Sul, Rio Grande do Sul State, Brazil] Cad Saúde Pública. 2008. 24(9):2043-53.

·         Gonçalves DM, Stein AT, Kapczinski F.[Performance of the Self-Reporting Questionnaire as a psychiatric screening questionnaire: a comparative study with Structured Clinical Interview for DSM-IV-TR] Cad Saúde Pública. 2008. 24(2):380-90. Para ver o artigo na íntegra, clique aqui

·         Guimarães LR, Jacka FN, Gama CS, Berk M, Leitão-Azevedo CL, Belmonte de Abreu MG, Lobato MI, Andreazza AC, Ceresér KM, Kapczinski F, Belmonte-de-Abreu P. Serum levels of brain-derived neurotrophic factor in schizophrenia on a hypocaloric diet. Prog Neuropsychopharmacol Biol Psychiatry. 2008. 32(6):1595-8.

·         Kapczinski F, Frey BN, Andreazza AC, Kauer-Sant'Anna M, Cunha ABM, Post RM. Increased oxidative stress as a mechanism for decreased BDNF levels in acute manic episodes. Rev Bras Psiquiatr. 2008. 30(3):243-45.

·         Kapczinski F, Frey BN, Kauer-Sant'Anna M, Grassi-Oliveira R. Brain-derived neurotrophic factor and neuroplasticity in bipolar disorder. Expert Rev Neurother. 2008. 8(7):1101-13. Review.

·         Kapczinski F, Kauer-Sant'anna M, Malhi GS, Dodd S, Berk M Reply. Acta Psychiatrica Scandinavica. 2008. 117: 398- 399.

·         Kapczinski F, Vieta E, Andreazza AC, Frey BN, Gomes FA, Tramontina J, Kauer-Sant'anna M, Grassi-Oliveira R, Post RM. Allostatic load in bipolar disorder: implications for pathophysiology and treatment. Neurosci Biobehav Rev. 2008. 32(4):675-92.

·         Kauer-Sant'anna M, Kapczinski F, Andreazza AC, Bond DJ, Lam RW, Trevor Young L, Yatham LN. Brain-derived neurotrophic factor and inflammatory markers in patients with early- vs. late-stage bipolar disorder. Int J Neuropsychopharmacol. 2008. 4:1-12.

·         Kauer-Sant'anna M, Yatham LN, Tramontina J, Weyne F, Cereser KM, Gazalle FK, Andreazza AC, Santin A, Quevedo J, Izquierdo I, Kapczinski F. Emotional memory in bipolar disorder. Br J Psychiatry. 2008. 192(6):458-63.

·         Kunz M, Gama CS, Andreazza AC, Salvador M, Ceresér KM, Gomes FA, Belmonte-de-Abreu PS, Berk M, Kapczinski F. Elevated serum superoxide dismutase and thiobarbituric acid reactive substances in different phases of bipolar disorder and in schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2008. 32(7):1677-1681.

·         Lucca G, Comim CM, Valvassori SS, Pereira JP, Stertz L, Gavioli EC, Kapczinski F, Quevedo J. Chronic Mild Stress Paradigm Reduces Sweet Food Intake in Rats without Affecting Brain Derived Neurotrophic Factor Protein Levels. Current Neurovascular Research. 2008. 5:207-213.

·         Machado-Vieira R, Soares JC, Lara DR, Luckenbaugh DA, Busnello JV, Marca G, Cunha A, Souza DO, Zarate CA Jr, Kapczinski F. A double-blind, randomized, placebo-controlled 4-week study on the efficacy and safety of the purinergic agents allopurinol and dipyridamole adjunctive to lithium in acute bipolar mania. J Clin Psychiatry. 2008. 69(8):1237-45.

·         Rosa AR, Andreazza AC, Kunz M, Gomes F, Santin A, Sanchez-Moreno J, Reinares M, Colom F, Vieta E, Kapczinski F. Predominant polarity in bipolar disorder: Diagnostic implications.. Journal of Affective Disorders. 2008. 107: 45-51. Para ver o artigo na íntegra, clique aqui

·         Rosa AR, Franco C, Martínez-Aran A, Sánchez-Moreno J, Reinares M, Salamero M, Arango C, Ayuso-Mateos JL, Kapczinski F, Vieta E. Functional impairment in patients with remitted bipolar disorder. Psychother Psychosom. 2008. 77(6):390-2.

·         Schneider JJ, Candiago RH, Rosa AR, Ceresér KM, Kapczinski F. Cognitive impairment in a Brazilian sample of patients with bipolar disorder. Rev Bras Psiquiatr 2008. 30(3):209-14.

·         Streck EL, Amboni G, Scaini G, Di-Pietro PB, Rezin GT, Valvassori SS, Luz G, Kapczinski F, Quevedo J. Brain creatine kinase activity in an animal model of mania. Life Sci. 2008. 82(7-8):424-9.

·         Valvassori SS, Petronilho FC, Réus GZ, Steckert AV, Oliveira VB, Boeck CR, Kapczinski F, Dal-Pizzol F, Quevedo J. Effect of N acetylcysteine and/or deferoxamine on oxidative stress and hyperactivity in an animal model of mania. Prog Neuropsychopharmacol Biol Psychiatry. 2008.32(4):1064-8.

·         Valvassori SS, Stertz L, Andreazza AC, Rosa MI, Kapczinski F, Streck EL, Quevedo J. Lack of effect of antipsychotics on BNDF and NGF levels in hippocampus of Wistar rats. Metab Brain Dis. 2008. 23(2):213-9.

·         Vargas HE, Gama CS, Andreazza AC, Medeiros D, Stertz L, Fries G, Palha J, Cereser KM, Berk M, Kapczinski F, Belmonte-de-Abreu PS. Decreased serum neurotrophin 3 in chronically medicated schizophrenic males. Neurosci Lett. 2008. 440(3):197-201.

·         Walz JC, Frey BN, Andreazza AC, Ceresér KMM, Cacilhas A, Valvassori SS, Quevedo J, Kapczinski F. Effects of lithium and valproate on serum and hippocampal neurotrophin-3 levels in an animal model of mania. Journal of Psychiatric Research. 2008. 42: 416-421. Para ver o artigo na íntegra, clique aqui

·         Walz JC, Magalhães PVS, Giglio LM, Cunha A, Stertz L, Fries GR, Andreazza AC, Kapczinski F. Increased serum neurotrophin-4/5 levels in bipolar disorder. Journal of Psychiatric Research. 2008. Epub ahead of print]

·         Yatham LN, Kapczinski F, Andreazza AC, Trevor Young L, Lam RW, Kauer-Sant'anna M. Accelerated age-related decrease in brain-derived neurotrophic factor levels in bipolar disorder. International Journal of Neuropsychopharmacology. 2008. 10:1- 3. Para ver o artigo na íntegra, clique aqui

·         Aguiar AS Jr, Tuon T, Pinho CA, Silva LA, Andreazza AC, Kapczinski F, Quevedo J, Streck EL, Pinho RA. Mitochondrial IV complex and brain neurothrophic derived factor responses of mice brain cortex after downhill training. Neurosci Lett. 2007. 426(3):171-4.

·         Andreazza AC, Cassini C, Rosa AR, Leite MC, de Almeida LM, Nardin P, Cunha AB, Ceresér KM, Santin A, Gottfried C, Salvador M, Kapczinski F, Gonçalves CA. Serum S100B and antioxidant enzymes in bipolar patients. J Psychiatr Res. 2007. 41(6):523-9.

·         Andreazza AC, Frey BN, Erdtmann B, Salvador M, Rombaldi F, Santin A, Gonçalves CA, Kapczinski F. DNA damage in bipolar disorder. Psychiatry Res. 2007.153(1):27-32. Para ver o artigo na íntegra, clique aqui

·         Andreazza AC, Frey BN, Valvassori SS, Zanotto C, Gomes KM, Comim CM, Cassini C, Stertz L, Ribeiro LC, Quevedo J, Kapczinski F, Berk M, Gonçalves CA. DNA damage in rats after treatment with methylphenidate. Prog Neuropsychopharmacol Biol Psychiatry. 2007. 31(6):1282-8.

·         Berk M, Dodd S, Kauer-Sant'anna M, Malhi GS, Bourin M, Kapczinski F, Norman T. Dopamine dysregulation syndrome: implications for a dopamine hypothesis of bipolar disorder. Acta Psychiatr Scand Suppl. 2007. 434:41-9. Review.

·         Corrêa C, Amboni G, Assis LC, Martins MR, Kapczinski F, Streck EL, Quevedo J. Effects of lithium and valproate on hippocampus citrate synthase activity in an animal model of mania. Prog Neuropsychopharmacol Biol Psychiatry. 2007. 31(4):887-91.

·         Frey BN, Andreazza AC, Nery FG, Martins MR, Quevedo J, Soares JC, Kapczinski F. The role of hippocampus in the pathophysiology of bipolar disorder. Behav Pharmacol. 2007. 18(5-6):419-30.

·         Frey BN, Stanley JA, Nery FG, Monkul ES, Nicoletti MA, Chen HH, Hatch JP, Caetano SC, Ortiz O, Kapczinski F, Soares JC. Abnormal cellular energy and phospholipid metabolism in the left dorsolateral prefrontal cortex of medication-free individuals with bipolar disorder: an in vivo 1H MRS study. Bipolar Disord. 2007. Suppl 1:119-27.

·         Frey BN, Andreazza AC, Kunz M, Gomes FA, Quevedo J, Salvador M, Gonçalves CA, Kapczinski F. Increased oxidative stress and DNA damage in bipolar disorder: a twin-case report. Prog Neuropsychopharmacol Biol Psychiatry. 2007. 31(1):283-5. Para ver o artigo na íntegra, clique aqui

·         Gama CS, Andreazza AC, Kunz M, Berk M, Belmonte-de-Abreu PS, Kapczinski F. Serum levels of brain-derived neurotrophic factor in patients with schizophrenia and bipolar disorder. Neurosci Lett. 2007. 420(1):45-48.

·         Gazalle FK, Frey BN, Hallal PC, Andreazza AC, Cunha AB, Santin A, Kapczinski F. Mismatch between self-reported quality of life and functional assessment in acute mania: a matter of unawareness of illness? J Affect Disord. 2007. 103(1-3):247-52. Para ver o artigo na íntegra, clique aqui

·         Gazalle FK, Hallal PC, Andreazza AC, Frey BN, Kauer-Sant'Anna M, Weyne F, da Costa SC, Santin A, Kapczinski F. Manic symptoms and quality of life in bipolar disorder. Psychiatry Res. 2007.153(1):33-8. Para ver o artigo na íntegra, clique aqui

·         Gazalle FK, Hallal PC, Tramontina J, Rosa AR, Andreazza AC, Zanatto V, Santin A, Kapczinski F, Ceresér KM. Polypharmacy and suicide attempts in bipolar disorder. Rev Bras Psiquiatr. 2007. 29(1):35-8. Para ver o artigo na íntegra, clique aqui

·         Kapczinski F.[Who reads (but does not quote) Brazilian science] Rev Bras Psiquiatr. 2007. 29(2):198.

·         Kauer-Sant'Anna M, Andreazza AC, Valvassori SS, Martins MR, Barbosa LM, Schwartsmann G, Roesler R, Quevedo J, Kapczinski F. A gastrin-releasing peptide receptor antagonist blocks D-amphetamine-induced hyperlocomotion and increases hippocampal NGF and BDNF levels in rats. Peptides. 2007. 28(7):1447-52.

·         Kauer-Sant'Anna M, Frey BN, Andreazza AC, Ceresér KM, Gazalle FK, Tramontina J, da Costa SC, Santin A, Kapczinski F. Anxiety comorbidity and quality of life in bipolar disorder patients. Can J Psychiatry. 2007. 52(3):175-81. Para ver o artigo na íntegra, clique aqui

·         Kauer-Sant'Anna M, Tramontina J, Andreazza AC, Cereser K, da Costa S, Santin A, Yatham LN, Kapczinski F. Traumatic life events in bipolar disorder: impact on BDNF levels and psychopathology. Bipolar Disord. 2007. Suppl 1:128-35. Para ver o artigo na íntegra, clique aqui

·         Kunz M, Gomes FA, Tramontina JF, Kapczinski F. Late-onset neuroleptic malignant syndrome in a patient using olanzapine. J Clin Psychopharmacol. 2007. 27(3):303-4.

·         Machado-Vieira R, Andreazza AC, Viale CI, Zanatto V, Cereser V Jr, da Silva Vargas R, Kapczinski F, Portela LV, Souza DO, Salvador M, Gentil V. Oxidative stress parameters in unmedicated and treated bipolar subjects during initial manic episode: a possible role for lithium antioxidant effects. Neurosci Lett. 2007. 421(1):33-6.

·         Machado-Vieira R, Dietrich MO, Leke R, Cereser VH, Zanatto V, Kapczinski F, Souza DO, Portela LV, Gentil V. Decreased plasma brain derived neurotrophic factor levels in unmedicated bipolar patients during manic episode. Biol Psychiatry. 2007. 61(2):142-4.

·         Preissler T, Luft T, Kapczinski F, Quevedo J, Schwartsmann G, Roesler R. Basic fibroblast growth factor prevents the memory impairment induced by gastrin-releasing peptide receptor antagonism in area CA1 of the rat hippocampus. Neurochem Res. 2007. 32(8):1381-6.

·         Ribeiro L, Andreazza AC, Salvador M, da Silveira TR, Vieira S, Nora DB, Bosa C, Di Napoli F, Schaf DV, Souza DO, Portela LV, Kapczinski F. Oxidative stress and S100B protein in cirrhotic children. Neurochem Res. 2007. 32(9):1600-3.

·         Roesler R, Kapczinski F, Quevedo J, Dal Pizzol F, Schwartsmann G. The gastrin-releasing peptide receptor as a therapeutic target in central nervous system disorders. Recent Patents CNS Drug Discov. 2007. 2(2):125-9.

·         Rosa AR, Andreazza AC, Gazalle FK, Sanchez-Moreno J, Santin A, Stein A, Barros HM, Vieta E, Kapczinski F. Adaptation and validation of the Portuguese version of the Lithium Knowledge Test(LKT) of bipolar patients treated with lithium: cross-over study. Clin Pract Epidemol Ment Health. 2006. 2:34. Para ver o artigo na íntegra, clique aqui

·         Rosa AR, Andreazza AC, Sanchez-Moreno J, Gazalle FK, Santin A, Stein A, Barros HM, Vieta E, Kapczinski F. Validation of the Portuguese version of the Lithium Attitudes Questionnaire (LAQ) in bipolar patients treated with lithium: cross-over study. Clin Pract Epidemol Ment Health. 2006. 2:32.

·         Rosa AR, Frey BN, Andreazza AC, Ceresér KM, Cunha AB, Quevedo J, Santin A, Gottfried C, Gonçalves CA, Vieta E, Kapczinski F.Increased serum glial cell line-derived neurotrophic factor immunocontent during manic and depressive episodes in individuals with bipolar disorder. Neurosci Lett. 2006. 407(2):146-50. Para ver o artigo na íntegra, clique aqui

·         Rosa AR, Marco M, Fachel JM, Kapczinski F, Stein AT, Barros HM. Correlation between drug treatment adherence and lithium treatment attitudes and knowledge by bipolar patients.Prog Neuropsychopharmacol Biol Psychiatry. 2007. 31(1):217-24.

·         Rosa AR, Sánchez-Moreno J, Martínez-Aran A, Salamero M, Torrent C, Reinares M, Comes M, Colom F, Van Riel W, Ayuso-Mateos JL, Kapczinski F, Vieta E. Validity and reliability of the Functioning Assessment Short Test (FAST) in bipolar disorder. Clin Pract Epidemol Ment Health. 2007. 3:5. Para ver o artigo na íntegra, clique aqui

·         Tramontina F, Leite MC, Cereser K, de Souza DF, Tramontina AC, Nardin P, Andreazza AC, Gottfried C, Kapczinski F, Gonçalves CA. Immunoassay for glial fibrillary acidic protein: antigen recognition is affected by its phosphorylation state. J Neurosci Methods. 2007. 162(1-2):282-6.

·         Tramontina J, Frey BN, Andreazza AC, Zandona M, Santin A, Kapczinski F.Val66met polymorphism and serum brain-derived neurotrophic factor levels in bipolar disorder. Mol Psychiatry. 2007. 12(3):230-1.

·         Valvassori SS, Frey BN, Martins MR, Réus GZ, Schimidtz F, Inácio CG, Kapczinski F, Quevedo J. Sensitization and cross-sensitization after chronic treatment with methylphenidate in adolescent Wistar rats. Behav Pharmacol. 2007. 18(3):205-12.

·         Walz JC, Andreazza AC, Frey BN, Cacilhas AA, Ceresér KM, Cunha AB, Weyne F, Stertz L, Santin A, Gonçalves CA, Kapczinski F. Serum neurotrophin-3 is increased during manic and depressive episodes in bipolar disorder. Neurosci Lett. 2007. 415(1):87-9. Para ver o artigo na íntegra, clique aqui

·         Busnello JV, Leke R, Oses JP, Feier G, Bruch R, Quevedo J, Kapczinski F,Souza DO, Cruz Portela LV. Acute and chronic electroconvulsive shock in rats: effects on peripheral markers of neuronal injury and glial activity.Life Sci. 2006. 78(26):3013-7.

·         Ceresér KM, Frey BN, Bernardes FB, Costa SC, Andreazza AC, Feier G, Souza D, Tramontina F, Gonçalves CA, Kapczinski F, Quevedo J. Glial fibrillary acidic protein expression after electroconvulsive shocks in rat brain. Prog Neuropsychopharmacol Biol Psychiatry. 2006. 30(4):663-7.

·         Chessick CA, Allen MH, Thase M, Batista Miralha da Cunha AB, Kapczinski FF, de Lima MS, dos Santos Souza JJ. Azapirones for generalized anxiety disorder. Cochrane Database Syst Rev. 2006. Jul 19;3:CD006115. Review.

·         Cunha AB, Frey BN, Andreazza AC, Goi JD, Rosa AR, Gonçalves CA, Santin A, Kapczinski F. Serum brain-derived neurotrophic factor is decreased in bipolar disorder during depressive and manic episodes. Neurosci Lett. 2006. 398(3):215-9. Para ver o artigo na íntegra, clique aqui

·         Fonseca M, Soares JC, Hatch JP, Santin AP, Kapczinski F. An open trial of adjunctive escitalopram in bipolar depression. J Clin Psychiatry. 2006. 67(1):81-6.

·         Frey BN, Andreazza AC, Ceresér KM, Martins MR, Petronilho FC, de Souza DF, Tramontina F, Gonçalves CA, Quevedo J, Kapczinski F. Evidence of astrogliosis in rat hippocampus after d-amphetamine exposure.Prog Neuropsychopharmacol Biol Psychiatry. 2006. 30(7):1231-4.

·         Frey BN, Andreazza AC, Ceresér KM, Martins MR, Valvassori SS, Réus GZ,Quevedo J, Kapczinski F. Effects of mood stabilizers on hippocampus BDNF levels in an animal model of mania.Life Sci. 2006. 79(3):281-6. Para ver o artigo na íntegra, clique aqui

·         Frey BN, Andreazza AC, Rosa AR, Martins MR, Valvassori SS, Réus GZ, Hatch JP, Quevedo J, Kapczinski F. Lithium increases nerve growth factor levels in the rat hippocampus in an animal model of mania. Behav Pharmacol. 2006. 17(4):311-8.

·         Frey BN, Martins MR, Petronilho FC, Dal-Pizzol F, Quevedo J, Kapczinski F. Increased oxidative stress after repeated amphetamine exposure: possible relevance as a model of mania. Bipolar Disord. 2006. 8(3):275-80.

·         Frey BN, Valvassori SS, Gomes KM, Martins MR, Dal-Pizzol F, Kapczinski F, Quevedo J. Increased oxidative stress in submitochondrial particles after chronic amphetamine exposure. Brain Res. 2006. 1097(1):224-9. Para ver o artigo na íntegra, clique aqui

·         Frey BN, Valvassori SS, Réus GZ, Martins MR, Petronilho FC, Bardini K, Dal-Pizzol F, Kapczinski F, Quevedo J. Effects of lithium and valproate on amphetamine-induced oxidative stress generation in an animal model of mania. J Psychiatry Neurosci. 2006. 31(5):326-32.

·         Frey BN, Valvassori SS, Réus GZ, Martins MR, Petronilho FC, Bardini K, Dal-Pizzol F, Kapczinski F, Quevedo J. Changes in antioxidant defense enzymes after d-amphetamine exposure: implications as an animal model of mania. Neurochem Res. 2006. 31(5):699-703.

·         Gama CS, Salvador M, Andreazza AC, Kapczinski F, Silva Belmonte-de-Abreu P. Elevated serum superoxide dismutase and thiobarbituric acid reactive substances in schizophrenia: a study of patients treated with haloperidol or clozapine. Prog Neuropsychopharmacol Biol Psychiatry. 2006. 30(3):512-5.

·         Gazalle FK, Andreazza AC, Hallal PC, Kauer-Sant'anna M, Ceresér KM, Soares JC, Santin A, Kapczinski F. Bipolar depression: the importance of being on remission. Rev Bras Psiquiatr. 2006. 28(2):93-6.

·         Gazalle FK, Kapczinski F. Bipolar disorder: building the path of return to the ideas of Kraepelin. Rev Bras Psiquiatr. 2006. 28(1):82. 72:

·         Gazalle FK, Kapczinski F.[Mogens Schou and the use of lithium in psychiatry]Rev Bras Psiquiatr. 2006. 28(1):82-3.

·         Frey BN, Folgierini M, Nicoletti M, Machado-Vieira R, Stanley JA, Soares JC, Kapczinski F.A proton magnetic resonance spectroscopy investigation of the dorsolateral prefrontal cortex in acute mania. Hum Psychopharmacol. 2005. 20(2):133-9.

·         Gazalle FK, Andreazza AC, Ceresér KM, Hallal PC, Santin A, Kapczinski F.Clinical impact of late diagnose of bipolar disorder. J Affect Disord. 2005. 86(2-3):313-6. Para ver o artigo na íntegra, clique aqui

·         Gazalle FK, Andreazza AC, Kauer-Sant'Anna M, Santin A, Kapczinski F. [Early diagnosis of bipolar disorder]Rev Bras Psiquiatr. 2005. 27(1):83-4.

·         Kapczinski F, Gentil V. CANMAT guidelines for bipolar disorder: a commentary from South America. Bipolar Disord. 2005. Suppl 3:87-8.

·         Schmitt R, Gazalle FK, Lima MS, Cunha A, Souza J, Kapczinski F.The efficacy of antidepressants for generalized anxiety disorder: a systematic review and meta-analysis. Rev Bras Psiquiatr. 2005. 27(1):18-24.

 

 

HOME  (Página Inicial)